Born in 1937 in Karachi India, in what became western Pakistan some ten years after her birth, Mohamedi lived, even from her early years, a cosmopolitan life.

Mohamedi's work defies categorisation; the result of a disciplined and sustained effort to craft an individual formal vocabulary, it remains without parallel, the product and artefact of Mohamedi's distinctive personality, process, and aesthetic values. In some of her early work, one can see attempts to capture the human form. She explored various mediums such as sketches, canvas based watercolour and oils to pencil and graphite. Her preferred medium of work was pencil and paper. She drew delicate but deliberate lines. She experimented with grid like formations and varying gradations at acute angles. What stood out in her works was her perception of light and shade.

The artist passed away in 1990.